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Karyopherin Alpha 1 (KPNa1)

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IPOA5; NPI-1; RCH2; SRP1; importin alpha 5; Nucleoprotein interactor 1; RAG cohort protein 2; SRP1-beta

Karyopherin Alpha 1 (KPNa1)
CCC E747
HGNC 6394
MGI 103560
PubMed 23425335
RGD 735064
UniProt P52294
Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. KPNa1 interacts with RAG1 and may play a role in V(D)J recombination. The authors obtained human and mouse cDNA sequences which are 98% identical as proteins. When RAG1 and human SRP1 were cotransfected into 293T cells a stable complex of the 2 was observed. The authors speculated that because SRP1 appears to be bound to the nuclear envelope, the interaction with RAG1 may serve to localize that protein to the envelope as well.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE747Hu01 Recombinant Karyopherin Alpha 1 (KPNa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE747Hu01 Polyclonal Antibody to Karyopherin Alpha 1 (KPNa1) WB; IHC; ICC; IP.
Assay Kits SEE747Hu ELISA Kit for Karyopherin Alpha 1 (KPNa1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Karyopherin Alpha 1 (KPNa1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Karyopherin Alpha 1 (KPNa1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Karyopherin Alpha 1 (KPNa1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Karyopherin Alpha 1 (KPNa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 1 (KPNa1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Karyopherin Alpha 1 (KPNa1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Karyopherin Alpha 1 (KPNa1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Karyopherin Alpha 1 (KPNa1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Karyopherin Alpha 1 (KPNa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Karyopherin Alpha 1 (KPNa1) ELISA Kit Customized Service Offer
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  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]