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Importin 5 (IPO5)

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RANBP5; IMB3; KPNB3; RANBP5; RAN Binding Protein 5; Karyopherin Beta 3; Importin subunit beta-3; Ran-binding protein 5

Importin 5 (IPO5)
CCC E754
HGNC 6402
MGI 1917822
PubMed 22730302
RGD 1308715
UniProt O00410
Wiki IPO5
The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. Importin 5 is a member of the importin beta family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE754Hu01 Recombinant Importin 5 (IPO5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Importin 5 (IPO5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 5 (IPO5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 5 (IPO5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 5 (IPO5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Importin 5 (IPO5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Importin 5 (IPO5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 5 (IPO5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 5 (IPO5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 5 (IPO5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Importin 5 (IPO5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Importin 5 (IPO5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 5 (IPO5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 5 (IPO5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 5 (IPO5) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human karyopherin beta3."Proc. Natl. Acad. Sci. U.S.A. 94:4451-4456(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1."Mol. Cell. Biol. 17:5087-5096(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAY-2006) to UniProtKB
  7. "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1."J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p."J. Mol. Biol. 425:1852-1868(2013) [PubMed] [Europe PMC] [Abstract]