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Importin 7 (IPO7)

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RANBP7; Imp7; RAN Binding Protein 7

Importin 7 (IPO7)
CCC E755
HGNC 9852
MGI 2152414
PubMed 22815235
RGD 1310849
UniProt O95373
Wiki IPO7
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE755Hu01 Recombinant Importin 7 (IPO7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Importin 7 (IPO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 7 (IPO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 7 (IPO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 7 (IPO7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Importin 7 (IPO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Importin 7 (IPO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 7 (IPO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 7 (IPO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 7 (IPO7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Importin 7 (IPO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Importin 7 (IPO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Importin 7 (IPO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Importin 7 (IPO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Importin 7 (IPO7) ELISA Kit Customized Service Offer
  1. "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A novel class of RanGTP binding proteins."J. Cell Biol. 138:65-80(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1."EMBO J. 18:2411-2423(1999) [PubMed] [Europe PMC] [Abstract]
  9. "CRM1-mediated recycling of snurportin 1 to the cytoplasm."J. Cell Biol. 145:255-264(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7."EMBO J. 22:3675-3685(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1."J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]