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Interleukin 23 Receptor (IL23R)

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Interleukin 23 Receptor (IL23R)
CCC E765
HGNC 19100
MGI 2181693
PubMed 22022372
RGD 1586368
UniProt Q5VWK5
Wiki IL23R
Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling.
This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE765Hu01 Recombinant Interleukin 23 Receptor (IL23R) Positive Control; Immunogen; SDS-PAGE; WB.
RPE765Hu02 Recombinant Interleukin 23 Receptor (IL23R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE765Hu01 Polyclonal Antibody to Interleukin 23 Receptor (IL23R) WB; IHC; ICC; IP.
MAE765Hu21 Monoclonal Antibody to Interleukin 23 Receptor (IL23R) WB; IHC; ICC; IP.
Assay Kits SEE765Hu ELISA Kit for Interleukin 23 Receptor (IL23R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 23 Receptor (IL23R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 23 Receptor (IL23R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 23 Receptor (IL23R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 23 Receptor (IL23R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 23 Receptor (IL23R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE765Ra01 Recombinant Interleukin 23 Receptor (IL23R) Positive Control; Immunogen; SDS-PAGE; WB.
EPE765Ra61 Eukaryotic Interleukin 23 Receptor (IL23R) Positive Control; Immunogen; SDS-PAGE; WB.
APE765Ra61 Active Interleukin 23 Receptor (IL23R) Cell culture; Activity Assays.
Antibodies PAE765Ra01 Polyclonal Antibody to Interleukin 23 Receptor (IL23R) WB; IHC; ICC; IP.
MAE765Ra21 Monoclonal Antibody to Interleukin 23 Receptor (IL23R) WB; IHC; ICC; IP.
Assay Kits SEE765Ra ELISA Kit for Interleukin 23 Receptor (IL23R) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R." J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells."Immunogenetics 57:934-943(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A genome-wide association study identifies IL23R as an inflammatory bowel disease gene." Science 314:1461-1463(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."Hum. Genet. 122:201-206(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Genome-wide association study for Crohn's disease in the Quebec founder population identifies multiple validated disease loci." Proc. Natl. Acad. Sci. U.S.A. 104:14747-14752(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."J. Invest. Dermatol. 129:355-358(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Glycosylation analysis of interleukin-23 receptor: elucidation of glycosylation sites and characterization of attached glycan structures."J. Mass Spectrom. 45:1416-1425(2010) [PubMed] [Europe PMC] [Abstract]