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Interleukin 22 Receptor Alpha 2 (IL22Ra2)

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CRF2-S1; IL-22BP; ZcytoR16; Cytokine receptor class-II member 10; Cytokine receptor family type 2, soluble 1; Interleukin-22-binding protein

Interleukin 22 Receptor Alpha 2 (IL22Ra2)
CCC E767
HGNC 14901
MGI 2665114
PubMed 24284923
RGD 1303169
UniProt Q969J5
Wiki IL22RA2
IL22Ra2 is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE767Hu01 Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE767Hu01 Polyclonal Antibody to Interleukin 22 Receptor Alpha 2 (IL22Ra2) WB; IHC; ICC; IP.
MAE767Hu21 Monoclonal Antibody to Interleukin 22 Receptor Alpha 2 (IL22Ra2) WB; IHC; ICC; IP.
Assay Kits SEE767Hu ELISA Kit for Interleukin 22 Receptor Alpha 2 (IL22Ra2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE767Mu01 Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE767Mu02 Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE767Mu01 Polyclonal Antibody to Interleukin 22 Receptor Alpha 2 (IL22Ra2) WB; IHC; ICC; IP.
PAE767Mu02 Polyclonal Antibody to Interleukin 22 Receptor Alpha 2 (IL22Ra2) WB; IHC; ICC; IP.
Assay Kits SEE767Mu ELISA Kit for Interleukin 22 Receptor Alpha 2 (IL22Ra2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE767Ra01 Recombinant Interleukin 22 Receptor Alpha 2 (IL22Ra2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE767Ra01 Polyclonal Antibody to Interleukin 22 Receptor Alpha 2 (IL22Ra2) WB; IHC; ICC; IP.
MAE767Ra21 Monoclonal Antibody to Interleukin 22 Receptor Alpha 2 (IL22Ra2) WB; IHC; ICC; IP.
Assay Kits SEE767Ra ELISA Kit for Interleukin 22 Receptor Alpha 2 (IL22Ra2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta."Genes Immun. 2:329-334(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity."J. Immunol. 166:7096-7103(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22."J. Immunol. 166:7090-7095(2001) [PubMed] [Europe PMC] [Abstract]
  4. "A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist." Proc. Natl. Acad. Sci. U.S.A. 98:9511-9516(2001) [PubMed] [Europe PMC] [Abstract]
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  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart."Genes Immun. 5:330-336(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cloning and characterization of mouse IL-22 binding protein."Genes Immun. 4:204-211(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22."FEBS Lett. 583:1072-1077(2009) [PubMed] [Europe PMC] [Abstract]