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WAS/WASL Interacting Protein Family, Member 1 (WIPF1)

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PRPL-2; WASPIP; WIP; Wiskott-Aldrich Syndrome Protein Interacting Protein

WAS/WASL Interacting Protein Family, Member 1 (WIPF1)
CCC E772
HGNC 12736
MGI 2178801
PubMed 19399471
RGD 620887
UniProt O43516
Wiki WIPF1
WAS/WASL-interacting protein family member 1 is a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. The size of platelets and lymphocytes is reduced in WAS, and scanning electron microscopy of T lymphocytes shows a relatively smooth surface with decrease in the number and size of microvilli, suggesting a defect in cytoskeletal architecture. The WAS gene encodes a 502-amino acid proline-rich protein (WASP).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE772Hu01 Recombinant WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WAS/WASL Interacting Protein Family, Member 1 (WIPF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WAS/WASL Interacting Protein Family, Member 1 (WIPF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WAS/WASL Interacting Protein Family, Member 1 (WIPF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WAS/WASL Interacting Protein Family, Member 1 (WIPF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WAS/WASL Interacting Protein Family, Member 1 (WIPF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WAS/WASL Interacting Protein Family, Member 1 (WIPF1) ELISA Kit Customized Service Offer
  1. "WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells."Proc. Natl. Acad. Sci. U.S.A. 94:14671-14676(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein."J. Immunol. 162:5019-5024(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization."Nat. Cell Biol. 2:441-448(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation."Mol. Biol. Cell 21:186-197(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP." J. Exp. Med. 209:29-34(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly."Proc. Natl. Acad. Sci. U.S.A. 102:16644-16649(2005) [PubMed] [Europe PMC] [Abstract]