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Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3)

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SCAR3; WAVE3; Verprolin homology domain-containing protein 3

Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3)
CCC E774
HGNC 12734
MGI 2658986
PubMed 22581642
UniProt Q9UPY6
Wiki WASF3
Wiskott-Aldrich syndrome protein family member 3 is a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
The Wiskott-Aldrich syndrome protein (WASP) and WASP-like (WASL) are among the downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. WASF1 is also involved in actin reorganization, but its expression is restricted to brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 3 (WASF3) ELISA Kit Customized Service Offer
  1. "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex."Biochem. Biophys. Res. Commun. 260:296-302(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and expression profile of the human and mouse WAVE gene family."Mamm. Genome 14:314-322(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration."J. Biol. Chem. 282:26257-26265(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]