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Annexin A8 (ANXA8)

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ANX8; ANX-A8; Vascular anticoagulant-beta

Annexin A8 (ANXA8)
CCC E785
HGNC 546
PubMed 19376120
UniProt P13928
Human annexin VIII was originally identified by Hauptmann et al. (1989) from a 2-kb cDNA transcript containing an open reading frame that encoded a 327-amino acid protein termed vascular anticoagulant beta. It is a minor annexin in human placenta and shows restricted expression in lung endothelia, skin, liver, and kidney. The gene is selectively overexpressed in acute myelocytic leukemia.
Affected human promyelocytes contain a nonrandom chromosomal translocation breakpoint involving chromosomes 15 and 17 and creating 2 hybrid mRNA fusion products and chimeric proteins. These involve the retinoic acid receptor-alpha gene (RARA) on chromosome 17q12 and the promyelocytic leukemia gene (PML; 102578) on chromosome 15q22.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE785Hu01 Recombinant Annexin A8 (ANXA8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE785Hu01 Polyclonal Antibody to Annexin A8 (ANXA8) WB; IHC; ICC; IP.
Assay Kits SEE785Hu ELISA Kit for Annexin A8 (ANXA8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE785Mu01 Recombinant Annexin A8 (ANXA8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Annexin A8 (ANXA8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Annexin A8 (ANXA8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Annexin A8 (ANXA8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Annexin A8 (ANXA8) ELISA Kit Customized Service Offer
  1. "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha."Eur. J. Biochem. 185:63-71(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Specific expression of the annexin VIII gene in acute promyelocytic leukemia."Blood 79:1802-1810(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The crystal structure of annexin A8 is similar to that of annexin A3."J. Mol. Biol. 345:1131-1139(2005) [PubMed] [Europe PMC] [Abstract]