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Nuclear Receptor Coactivator 4 (NCOA4)

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ARA70; ELE1; PTC3; RFG; RET-Activating Gene ELE1; Androgen receptor coactivator 70 kDa protein; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1

Nuclear Receptor Coactivator 4 (NCOA4)
CCC E794
HGNC 7671
MGI 1350932
PubMed 22887727
UniProt Q13772
Wiki NCOA4
NCOA4 interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.The interaction between the AR bait and NCOA4 occurred only in the presence of dihydrotestosterone. The deduced 614-amino acid protein has a calculated molecular mass of 70 kD.mouse tissues detected highest expression of Ara70 in thymus, prostate, testis, and adrenal gland. Intermediate expression was found in several other mouse tissues, and no expression was detected in brain cortex, liver, spleen, and seminal vesicle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Coactivator 4 (NCOA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 4 (NCOA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 4 (NCOA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 4 (NCOA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 4 (NCOA4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Coactivator 4 (NCOA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 4 (NCOA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 4 (NCOA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 4 (NCOA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 4 (NCOA4) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells."Proc. Natl. Acad. Sci. U.S.A. 93:5517-5521(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma."Oncogene 9:509-516(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas."Cancer Res. 54:2979-2985(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform."Mol. Endocrinol. 13:117-128(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma."J. Biol. Chem. 274:16147-16152(1999) [PubMed] [Europe PMC] [Abstract]