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Nuclear Receptor Coactivator 2 (NCOA2)

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GRIP1; TIF2; SRC-2; BHLHE75; Glucocorticoid Receptor Interacting Protein 1; Class E basic helix-loop-helix protein 75; Transcriptional Mediators/Intermediary Factor 2

Nuclear Receptor Coactivator 2 (NCOA2)
CCC E799
HGNC 7669
MGI 1276533
PubMed 22034177
RGD 620108
UniProt Q15596
Wiki NCOA2
Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain.
The nuclear receptor coactivator 2 (NCOA2) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA2 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA2 assists nuclear receptors in the upregulation of DNA expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Coactivator 2 (NCOA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 2 (NCOA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 2 (NCOA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 2 (NCOA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 2 (NCOA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Coactivator 2 (NCOA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 2 (NCOA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 2 (NCOA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 2 (NCOA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 2 (NCOA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Coactivator 2 (NCOA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Coactivator 2 (NCOA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Coactivator 2 (NCOA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Coactivator 2 (NCOA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Coactivator 2 (NCOA2) ELISA Kit Customized Service Offer
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  19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity."Mol. Cell. Biol. 33:2116-2127(2013) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]