≡

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)

[Edit]

NMDAR2B; NR2B; hNR3; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)
CCC E807
HGNC 4586
MGI 95821
PubMed 21499247
RGD 2738
UniProt Q13224
Wiki GRIN2B
The N-methyl-D-aspartate (NMDA) receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. Functional NMDA receptors appear to be composed (minimally) of an invariant subunit (NMDAR1) and 1 of several variable subunits . Each of the variable subunits exhibits a distinct distribution in the adult brain. For example, postnatally, NMDA receptors containing the NMDAR2B subunit are primarily localized to the hippocampus and forebrain. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse Nmdar2b proteins, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE807Hu01 Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE807Hu21 Monoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) WB; IHC; ICC; IP.
PAE807Hu01 Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) WB; IHC; ICC; IP.
MAE807Hu22 Monoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) WB; IHC; ICC; IP.
MAE807Hu23 Monoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) WB; IHC; ICC; IP.
Assay Kits SEE807Hu ELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Enzyme-linked immunosorbent assay for Antigen Detection.
AEE807Hu ELISA Kit for Anti-Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B Antibody (Anti-GRIN2B) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Recombinant Protein Customized Service Offer
Antibodies PAE807Mu01 Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) WB; IHC; ICC; IP.
Assay Kits SEE807Mu ELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPE807Ra21 OVA Conjugated Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Polyclonal Antibody Customized Service Offer
Assay Kits SEE807Ra ELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein."Biochim. Biophys. Acta 1260:105-108(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors."J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12."Genomics 22:216-218(1994) [PubMed] [Europe PMC] [Abstract]
  5. "mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit."Neurosci. Lett. 239:49-53(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."J. Biol. Chem. 275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes." Nat. Genet. 42:1021-1026(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
  9. "GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy."Ann. Neurol. 75:147-154(2014) [PubMed] [Europe PMC] [Abstract]