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Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)

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IP3R; IP3R1; Insp3r1; SCA15; SCA16; Spinocerebellar Ataxia 15; IP3 receptor isoform 1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor

Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)
CCC E845
HGNC 6180
MGI 96623
PubMed 22986007
RGD 2933
UniProt Q14643
Wiki ITPR1
ITPR1 encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. Inositol 1,4,5-triphosphate is an intracellular second messenger produced by phospholipase C through a G protein-dependent mechanism. It releases calcium from endoplasmic reticulum by binding to specific receptors that are coupled to calcium channels. These receptors are abundant in neuronal and nonneuronal tissues. The neuronal form of the receptor is abundant in the cerebellum, particularly the perikaryon of the Purkinje cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE845Hu01 Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) ELISA Kit Customized Service Offer
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  2. "The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation."J. Biol. Chem. 270:2833-2840(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant."Brain Res. Mol. Brain Res. 32:291-296(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
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  6. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins."EMBO J. 23:312-321(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44."Cell 120:85-98(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation."Blood 109:552-559(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans." PLoS Genet. 3:1076-1082(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes."FEBS Open Bio 2:255-259(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families."Neurology 71:547-551(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Missense mutations in ITPR1 cause autosomal dominant congenital nonprogressive spinocerebellar ataxia."Orphanet J. Rare Dis. 7:67-67(2012) [PubMed] [Europe PMC] [Abstract]