≡

Diacylglycerol Kinase Zeta (DGKz)

[Edit]

DAGK5; DAGK6; DGK-ZETA; hDGKzeta; Diglyceride kinase zeta

Diacylglycerol Kinase Zeta (DGKz)
CCC E854
HGNC 2857
MGI 1278339
PubMed 8626588
RGD 70929
UniProt Q13574
Wiki DGKZ
Diacylglycerol kinase zeta is an enzyme belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Human DGK-zeta contains 2 zinc fingers, an ATP-binding site, and 4 ankyrin repeats near the C terminus. A unique feature, as compared with other DGKs, is the presence of a sequence homologous to the MARCKS phosphorylation site domain. Northern blot analysis of multiple tissues showed that DGK-zeta is expressed at highest levels in brain and muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE854Hu01 Recombinant Diacylglycerol Kinase Zeta (DGKz) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE854Hu01 Polyclonal Antibody to Diacylglycerol Kinase Zeta (DGKz) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Diacylglycerol Kinase Zeta (DGKz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diacylglycerol Kinase Zeta (DGKz) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE854Mu01 Recombinant Diacylglycerol Kinase Zeta (DGKz) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE854Mu01 Polyclonal Antibody to Diacylglycerol Kinase Zeta (DGKz) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Diacylglycerol Kinase Zeta (DGKz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diacylglycerol Kinase Zeta (DGKz) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diacylglycerol Kinase Zeta (DGKz) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diacylglycerol Kinase Zeta (DGKz) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diacylglycerol Kinase Zeta (DGKz) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diacylglycerol Kinase Zeta (DGKz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diacylglycerol Kinase Zeta (DGKz) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta."J. Biol. Chem. 271:10230-10236(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing of the human diacylglycerol kinase zeta gene in muscle."Proc. Natl. Acad. Sci. U.S.A. 94:5519-5524(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta."Nature 394:697-700(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions."J. Biol. Chem. 276:26526-26533(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism."J. Cell Biol. 152:1135-1143(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling."Mol. Cell. Proteomics 6:1073-1087(2007) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]