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Alcohol Dehydrogenase 5 (ADH5)

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ADHX; FDH; Formaldehyde Dehydrogenase; Alcohol dehydrogenase class-3; Glutathione-dependent formaldehyde dehydrogenase; S-(hydroxymethyl)glutathione dehydrogenase

Alcohol Dehydrogenase 5 (ADH5)
CCC E864
HGNC 253
MGI 87929
PubMed 23355119
UniProt P11766
Wiki ADH5
ADH5 encodes glutathione-dependent formaldehyde dehydrogenase or class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alcohol Dehydrogenase 5 (ADH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alcohol Dehydrogenase 5 (ADH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alcohol Dehydrogenase 5 (ADH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase 5 (ADH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase 5 (ADH5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alcohol Dehydrogenase 5 (ADH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alcohol Dehydrogenase 5 (ADH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alcohol Dehydrogenase 5 (ADH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase 5 (ADH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase 5 (ADH5) ELISA Kit Customized Service Offer
  1. "cDNA sequence of human class III alcohol dehydrogenase."Biochem. Biophys. Res. Commun. 164:631-637(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA."Biochem. Biophys. Res. Commun. 164:453-460(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase."Gene 121:305-311(1992) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes."Biochemistry 27:1132-1140(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase."Biochemistry 32:5139-5144(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation."Proc. Natl. Acad. Sci. U.S.A. 90:2491-2494(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase."J. Mol. Biol. 265:330-343(1997) [PubMed] [Europe PMC] [Abstract]