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Alcohol Dehydrogenase 7 (ADH7)

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Alcohol dehydrogenase class 4 mu/sigma chain; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase

Alcohol Dehydrogenase 7 (ADH7)
CCC E866
HGNC 256
MGI 87926
PubMed 22144473
RGD 621638
UniProt P40394
Wiki ADH7
ADH7 encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products.
The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alcohol Dehydrogenase 7 (ADH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alcohol Dehydrogenase 7 (ADH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alcohol Dehydrogenase 7 (ADH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase 7 (ADH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase 7 (ADH7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE866Mu01 Recombinant Alcohol Dehydrogenase 7 (ADH7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE866Mu01 Polyclonal Antibody to Alcohol Dehydrogenase 7 (ADH7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase 7 (ADH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase 7 (ADH7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alcohol Dehydrogenase 7 (ADH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alcohol Dehydrogenase 7 (ADH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alcohol Dehydrogenase 7 (ADH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alcohol Dehydrogenase 7 (ADH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alcohol Dehydrogenase 7 (ADH7) ELISA Kit Customized Service Offer
  1. "Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships."Eur. J. Biochem. 224:549-557(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene."J. Biol. Chem. 269:15606-15612(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro."J. Biol. Chem. 270:4305-4311(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7)."FEBS Lett. 351:411-415(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes."J. Biol. Chem. 270:3625-3630(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH."Genomics 31:243-245(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class."FEBS Lett. 303:69-72(1992) [PubMed] [Europe PMC] [Abstract]
  11. "Human stomach class IV alcohol dehydrogenase: molecular genetic analysis."Alcohol. Clin. Exp. Res. 19:185-186(1995) [PubMed] [Europe PMC] [Abstract]
  12. "X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity."J. Biol. Chem. 272:18558-18563(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase."Protein Sci. 8:2639-2644(1999) [PubMed] [Europe PMC] [Abstract]