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Sorting Nexin 2 (SNX2)

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TRG-9; Transformation-related gene 9 protein

Sorting Nexin 2 (SNX2)
CCC E872
HGNC 11173
MGI 1915054
PubMed 24215620
RGD 1310291
UniProt O60749
Wiki SNX2
Sorting nexin-2 is member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.
The SNX2 cDNA encodes a deduced 519-amino acid protein that shares 63% sequence identity with SNX1. Northern blot analysis detected SNX2 transcripts of approximately 3.1 and 2.4 kb in all tissues tested, with highest expression in spleen, heart, skeletal muscle, and peripheral leukocytes, and low expression in kidney, liver, and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 2 (SNX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 2 (SNX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 2 (SNX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 2 (SNX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 2 (SNX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 2 (SNX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 2 (SNX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 2 (SNX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 2 (SNX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 2 (SNX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 2 (SNX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 2 (SNX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 2 (SNX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 2 (SNX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 2 (SNX2) ELISA Kit Customized Service Offer
  1. "Identification of a family of sorting nexin molecules and characterization of their association with receptors."Mol. Cell. Biol. 18:7278-7287(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."Mol. Biol. Cell 11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia."Proc. Natl. Acad. Sci. U.S.A. 98:8756-8761(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance."FEBS Lett. 554:10-16(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport."J. Cell Sci. 118:4527-4539(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors."Mol. Cell. Biol. 27:1112-1124(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors."Traffic 9:380-393(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport."Cell Res. 19:1334-1349(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network."Dev. Cell 17:110-122(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Amphipathic motifs in BAR domains are essential for membrane curvature sensing."EMBO J. 28:3303-3314(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin."Eur. J. Cell Biol. 89:379-393(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling."Traffic 11:1347-1362(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules."EMBO J. 31:4466-4480(2012) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]