≡

Sorting Nexin 5 (SNX5)

[Edit]

Sorting Nexin 5 (SNX5)
CCC E875
HGNC 14969
MGI 1916428
PubMed 10600472
RGD 1310190
UniProt Q9Y5X3
Wiki SNX5
Sorting nexin-5 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.Northern blot analysis detected 2 SNX5 transcripts of 2.2 and 1.6 kb, which were present in varying amounts among the tissues and cell lines tested. The highest levels were found in skeletal muscle and kidney as well as in a T-cell leukemia, a colon adenocarcinoma, and a lung carcinoma cell line, and the lowest levels were found in brain, placenta, lung, and liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 5 (SNX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 5 (SNX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 5 (SNX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 5 (SNX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 5 (SNX5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 5 (SNX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 5 (SNX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 5 (SNX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 5 (SNX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 5 (SNX5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 5 (SNX5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 5 (SNX5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 5 (SNX5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 5 (SNX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 5 (SNX5) ELISA Kit Customized Service Offer
  1. "A large family of endosome-localized proteins related to sorting nexin 1."Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation."J. Cell Sci. 117:6413-6424(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish."FEBS Lett. 580:4409-4416(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Visualisation of macropinosome maturation by the recruitment of sorting nexins."J. Cell Sci. 119:3967-3980(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer."J. Cell Sci. 120:45-54(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A role for SNX5 in the regulation of macropinocytosis."BMC Cell Biol. 9:58-58(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport."Mol. Biol. Cell 19:3823-3835(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network."Dev. Cell 17:110-122(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins."PLoS ONE 5:E13763-E13763(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules."EMBO J. 31:4466-4480(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Endosomal type Igamma PIP 5-kinase controls EGF receptor lysosomal sorting."Dev. Cell 25:144-155(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Isoform 5 of PIPKIgamma regulates the endosomal trafficking and degradation of E-cadherin."J. Cell Sci. 127:2189-2203(2014) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion."J. Exp. Med. 200:13-24(2004) [PubMed] [Europe PMC] [Abstract]