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Sorting Nexin 6 (SNX6)

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TRAF4-associated factor 2

Sorting Nexin 6 (SNX6)
CCC E876
HGNC 14970
MGI 1919433
PubMed 19935774
RGD 1304647
UniProt Q9UNH7
Wiki Snx6
Sorting Nexin 6 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 6 (SNX6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 6 (SNX6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 6 (SNX6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 6 (SNX6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 6 (SNX6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 6 (SNX6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 6 (SNX6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 6 (SNX6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 6 (SNX6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 6 (SNX6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 6 (SNX6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 6 (SNX6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 6 (SNX6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 6 (SNX6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 6 (SNX6) ELISA Kit Customized Service Offer
  1. "A large family of endosome-localized proteins related to sorting nexin 1."Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus."FEBS Lett. 506:33-38(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases."J. Biol. Chem. 276:19332-19339(2001) [PubMed] [Europe PMC] [Abstract]
  6. "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer."J. Cell Sci. 120:45-54(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport."Cell Res. 19:1334-1349(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network."Dev. Cell 17:110-122(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing."FASEB J. 24:2783-2794(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression."J. Cell. Biochem. 111:1464-1472(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules."EMBO J. 31:4466-4480(2012) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Isoform 5 of PIPKIgamma regulates the endosomal trafficking and degradation of E-cadherin."J. Cell Sci. 127:2189-2203(2014) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]