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Sorting Nexin 9 (SNX9)

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SDP1; SH3PX1; SH3PXD3A; WISP; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A

Sorting Nexin 9 (SNX9)
CCC E879
HGNC 14973
MGI 1913866
PubMed 18388313
UniProt Q9Y5X1
Wiki SNX9
Sorting nexin-9 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE879Hu01 Recombinant Sorting Nexin 9 (SNX9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE879Hu01 Polyclonal Antibody to Sorting Nexin 9 (SNX9) WB; IHC
MAE879Hu21 Monoclonal Antibody to Sorting Nexin 9 (SNX9) WB; IHC; ICC; IP.
Assay Kits SEE879Hu ELISA Kit for Sorting Nexin 9 (SNX9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 9 (SNX9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 9 (SNX9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 9 (SNX9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 9 (SNX9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 9 (SNX9) ELISA Kit Customized Service Offer
  1. "A large family of endosome-localized proteins related to sorting nexin 1."Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation."J. Biol. Chem. 277:10134-10138(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components."J. Biol. Chem. 278:46772-46781(2003) [PubMed] [Europe PMC] [Abstract]
  7. "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1."FEBS Lett. 579:5040-5048(2005) [PubMed] [Europe PMC] [Abstract]
  8. "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis."Mol. Biol. Cell 16:2058-2067(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2."Biochem. J. 394:693-698(2006) [PubMed] [Europe PMC] [Abstract]
  10. "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis."Dev. Cell 13:43-56(2007) [PubMed] [Europe PMC] [Abstract]
  11. "SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2."J. Cell Sci. 121:1252-1263(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain."FEBS J. 277:2803-2814(2010) [PubMed] [Europe PMC] [Abstract]
  15. "SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane."J. Cell Sci. 123:1742-1750(2010) [PubMed] [Europe PMC] [Abstract]
  16. "The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins."PLoS ONE 5:E13763-E13763(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis."J. Cell Sci. 125:4372-4382(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "The PX-BAR membrane-remodeling unit of sorting nexin 9."EMBO J. 26:4788-4800(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Structure and plasticity of Endophilin and Sorting Nexin 9."Structure 16:1574-1587(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Mechanism of aldolase control of sorting nexin 9 function in endocytosis."J. Biol. Chem. 285:11983-11990(2010) [PubMed] [Europe PMC] [Abstract]