≡

Sorting Nexin 28 (SNX28)

[Edit]

NOXO1; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5; NADPH Oxidase Organizer 1; NADPH oxidase regulatory protein; SH3 and PX domain-containing protein 5

Sorting Nexin 28 (SNX28)
CCC E880
HGNC 19404
MGI 1919143
PubMed 12473664
RGD 1307802
UniProt Q8NFA2
Wiki SNX28
NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to generate reactive oxygen species (ROS). NOX organizers, such as NOXO1, target NOX activators to NOX and also target NOX to different subcellular compartments.
NOXO1 was expressed throughout the gastrointestinal tract, including all regions of small and large intestine. PCR analysis using specific primers showed that NOXO1-beta was the major mRNA in colon and fetal liver, and that NOXO1-gamma was the major mRNA in testis. Neither NOXO1-alpha nor NOXO1-delta were expressed at significant levels in any tissue tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 28 (SNX28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 28 (SNX28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 28 (SNX28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 28 (SNX28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 28 (SNX28) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 28 (SNX28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 28 (SNX28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 28 (SNX28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 28 (SNX28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 28 (SNX28) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorting Nexin 28 (SNX28) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorting Nexin 28 (SNX28) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorting Nexin 28 (SNX28) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorting Nexin 28 (SNX28) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorting Nexin 28 (SNX28) ELISA Kit Customized Service Offer
  1. "Two novel proteins activate superoxide generation by the NADPH oxidase NOX1."J. Biol. Chem. 278:3510-3513(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells."J. Biol. Chem. 278:20006-20012(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases."J. Biol. Chem. 278:25234-25246(2003) [PubMed] [Europe PMC] [Abstract]
  4. "NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain."J. Biol. Chem. 279:4737-4742(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3."Gene 356:118-126(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "NOX3, a superoxide-generating NADPH oxidase of the inner ear."J. Biol. Chem. 279:46065-46072(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators."J. Biol. Chem. 280:23328-23339(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1."Biochem. Biophys. Res. Commun. 339:985-990(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1)."Biochem. Biophys. Res. Commun. 352:560-565(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity."Sci. Signal. 2:RA54-RA54(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation."Eur. J. Cell Biol. 90:164-171(2011) [PubMed] [Europe PMC] [Abstract]