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A Kinase Anchor Protein 13 (AKAP13)

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AKAP-Lbc; BRX; HA-3; Ht31; LBC; C-lbc; Lymphoid Blast Crisis Oncogene; Breast cancer nuclear receptor-binding auxiliary protein; Human thyroid-anchoring protein 31

A Kinase Anchor Protein 13 (AKAP13)
CCC E893
HGNC 371
MGI 2676556
PubMed 23658642
RGD 727893
UniProt Q12802
Wiki AKAP13
AKAP13 encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals.
Akap13 was expressed in embryonic mouse forebrain, limb bud, first brachial arch, and developing heart. Newborn and adult mouse heart expressed the full-length transcript. Immunohistochemical analysis revealed strong Akap13 staining of the myocardium and colocalization of Akap13 with cytoskeletal filaments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 13 (AKAP13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 13 (AKAP13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 13 (AKAP13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 13 (AKAP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 13 (AKAP13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 13 (AKAP13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 13 (AKAP13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 13 (AKAP13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 13 (AKAP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 13 (AKAP13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 13 (AKAP13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 13 (AKAP13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 13 (AKAP13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 13 (AKAP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 13 (AKAP13) ELISA Kit Customized Service Offer
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  2. "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation."J. Biol. Chem. 276:44247-44257(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting."Mol. Cell. Biol. 19:1334-1345(1999) [PubMed] [Europe PMC] [Abstract]
  6. ErratumMol. Cell. Biol. 19:3930-3930(1999)
  7. "Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products."Oncogene 9:621-628(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain."J. Biol. Chem. 267:13376-13382(1992) [PubMed] [Europe PMC] [Abstract]
  9. "The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway."J. Biol. Chem. 276:46792-46797(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2."Biochem. Biophys. Res. Commun. 320:1063-1068(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes."EMBO J. 20:1651-1662(2001) [PubMed] [Europe PMC] [Abstract]