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A Kinase Anchor Protein 5 (AKAP5)

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AKAP75; AKAP79; H21; A-kinase anchor protein 79 kDa; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

A Kinase Anchor Protein 5 (AKAP5)
CCC E895
HGNC 375
MGI 2685104
PubMed 22232585
RGD 620829
UniProt P24588
Wiki AKAP5
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family.
AKAP5 binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 5 (AKAP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 5 (AKAP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 5 (AKAP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 5 (AKAP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 5 (AKAP5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE895Mu01 Recombinant A Kinase Anchor Protein 5 (AKAP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 5 (AKAP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 5 (AKAP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 5 (AKAP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 5 (AKAP5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Kinase Anchor Protein 5 (AKAP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Kinase Anchor Protein 5 (AKAP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Kinase Anchor Protein 5 (AKAP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Kinase Anchor Protein 5 (AKAP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Kinase Anchor Protein 5 (AKAP5) ELISA Kit Customized Service Offer
  1. "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79."J. Biol. Chem. 267:16816-16823(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta."J. Biol. Chem. 267:2131-2134(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8."J. Biol. Chem. 286:32962-32975(2011) [PubMed] [Europe PMC] [Abstract]