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Catenin Delta 1 (CTNNd1)

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CAS; CTNND; P120CAS; P120CTN; p120; Cadherin-Associated Protein Delta 1; Cadherin-associated Src substrate

Catenin Delta 1 (CTNNd1)
CCC E901
HGNC 2515
MGI 105100
PubMed 9653641
RGD 1305643
UniProt O60716
Wiki CTNND1
Catenins were discovered as proteins that are linked ('catena' means 'chain' in Latin) to the cytoplasmic domain of transmembrane cadherin proteins. Delta-catenin, also called CAS, p120(cas), or p120(ctn), is a tyrosine kinase substrate implicated in ligand-induced receptor signaling through the EGF receptor, the PDGF receptor (PDGFR), and the CSF1 receptor, as well as in cell transformation by SRC.
Catenin delta-1 is a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and althernative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE901Hu01 Recombinant Catenin Delta 1 (CTNNd1) Positive Control; Immunogen; SDS-PAGE; WB.
EPE901Hu61 Eukaryotic Catenin Delta 1 (CTNNd1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Catenin Delta 1 (CTNNd1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Catenin Delta 1 (CTNNd1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Catenin Delta 1 (CTNNd1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Catenin Delta 1 (CTNNd1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Catenin Delta 1 (CTNNd1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Catenin Delta 1 (CTNNd1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Catenin Delta 1 (CTNNd1) Polyclonal Antibody Customized Service Offer
Assay Kits SEE901Mu ELISA Kit for Catenin Delta 1 (CTNNd1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Catenin Delta 1 (CTNNd1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Catenin Delta 1 (CTNNd1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Catenin Delta 1 (CTNNd1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Catenin Delta 1 (CTNNd1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Catenin Delta 1 (CTNNd1) ELISA Kit Customized Service Offer
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  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors."Mol. Cell. Biol. 15:4553-4561(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor."Mol. Cell. Biol. 19:3614-3623(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells."J. Cell Sci. 115:1391-1402(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)."Oncogene 21:7067-7076(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells."J. Biol. Chem. 279:11417-11424(2004) [PubMed] [Europe PMC] [Abstract]
  11. "E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion."Cancer Res. 66:10007-10015(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  14. "The armadillo protein p0071 regulates Rho signalling during cytokinesis."Nat. Cell Biol. 8:1432-1440(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  16. "The transcriptional repressor Glis2 is a novel binding partner for p120 catenin."Mol. Biol. Cell 18:1918-1927(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA."Mol. Cell. Biol. 27:1745-1757(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "p120-catenin is a binding partner and substrate for Group B Pak kinases."J. Cell. Biochem. 110:1244-1254(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  26. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  28. "Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion."Cell 141:117-128(2010) [PubMed] [Europe PMC] [Abstract]