≡

Histone Deacetylase 3 (HDAC3)

[Edit]

RPD3; HD3; RPD3-2; SMAP45

Histone Deacetylase 3 (HDAC3)
CCC E903
HGNC 4854
MGI 1343091
PubMed 21075309
RGD 619977
UniProt O15379
Wiki HDAC3
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE903Hu01 Recombinant Histone Deacetylase 3 (HDAC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 3 (HDAC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 3 (HDAC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 3 (HDAC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 3 (HDAC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Deacetylase 3 (HDAC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 3 (HDAC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 3 (HDAC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 3 (HDAC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 3 (HDAC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE903Ra01 Recombinant Histone Deacetylase 3 (HDAC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 3 (HDAC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 3 (HDAC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 3 (HDAC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 3 (HDAC3) ELISA Kit Customized Service Offer
  1. "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells."Biochem. Biophys. Res. Commun. 242:648-652(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family."J. Biol. Chem. 272:28001-28007(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of a human RPD3 ortholog, HDAC3."Proc. Natl. Acad. Sci. U.S.A. 95:2795-2800(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization and chromosomal localization of the human histone deacetylase 3 gene."Genomics 56:197-202(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing."J. Biol. Chem. 275:40782-40787(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Sequestration and inhibition of Daxx-mediated transcriptional repression by PML."Mol. Cell. Biol. 20:1784-1796(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5."Proc. Natl. Acad. Sci. U.S.A. 97:1056-1061(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The histone deacetylase-3 complex contains nuclear receptor corepressors."Proc. Natl. Acad. Sci. U.S.A. 97:7202-7207(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo."J. Biol. Chem. 276:35826-35835(2001) [PubMed] [Europe PMC] [Abstract]
  11. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain."Nucleic Acids Res. 30:1114-1123(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."EMBO J. 21:2682-2691(2002) [PubMed] [Europe PMC] [Abstract]
  14. "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness."Genes Dev. 14:1048-1057(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3."EMBO J. 19:4342-4350(2000) [PubMed] [Europe PMC] [Abstract]
  16. "BCoR, a novel corepressor involved in BCL-6 repression."Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract]
  17. "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1."EMBO J. 22:1336-1346(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene."EMBO J. 22:6299-6309(2003) [PubMed] [Europe PMC] [Abstract]
  20. "DACH1 inhibits transforming growth factor-beta signaling through binding Smad4."J. Biol. Chem. 278:51673-51684(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Regulation of human SRY subcellular distribution by its acetylation/deacetylation."EMBO J. 23:3336-3345(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein."J. Biol. Chem. 280:28507-28518(2005) [PubMed] [Europe PMC] [Abstract]
  23. "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."Biochem. J. 397:169-177(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription."J. Endocrinol. 198:29-39(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
  27. "NKAP is a transcriptional repressor of notch signaling and is required for T cell development."Immunity 30:696-707(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes."Mol. Cell. Biol. 31:2349-2363(2011) [PubMed] [Europe PMC] [Abstract]
  31. "A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters."Cell Rep. 4:578-588(2013) [PubMed] [Europe PMC] [Abstract]
  32. "Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3."J. Biol. Chem. 289:30625-30634(2014) [PubMed] [Europe PMC] [Abstract]