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Histone Deacetylase 4 (HDAC4)

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HD4; HDAC-A; HDACA

Histone Deacetylase 4 (HDAC4)
CCC E904
HGNC 14063
MGI 3036234
PubMed 23434587
RGD 619979
UniProt P56524
Wiki HDAC4
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC4belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.[3] Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE904Hu01 Recombinant Histone Deacetylase 4 (HDAC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE904Hu21 Monoclonal Antibody to Histone Deacetylase 4 (HDAC4) WB; IHC; ICC; IP.
PAE904Hu01 Polyclonal Antibody to Histone Deacetylase 4 (HDAC4) WB; IHC; ICC; IP.
Assay Kits SEE904Hu ELISA Kit for Histone Deacetylase 4 (HDAC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE904Mu01 Recombinant Histone Deacetylase 4 (HDAC4) Positive Control; Immunogen; SDS-PAGE; WB.
RPE904Mu02 Recombinant Histone Deacetylase 4 (HDAC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE904Mu01 Polyclonal Antibody to Histone Deacetylase 4 (HDAC4) WB; IHC; ICC; IP; FCM
PAE904Mu02 Polyclonal Antibody to Histone Deacetylase 4 (HDAC4) WB; IHC; ICC; IP.
Assay Kits SEE904Mu ELISA Kit for Histone Deacetylase 4 (HDAC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Deacetylase 4 (HDAC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 4 (HDAC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 4 (HDAC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 4 (HDAC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 4 (HDAC4) ELISA Kit Customized Service Offer
  1. "Three proteins define a class of human histone deacetylases related to yeast Hda1p."Proc. Natl. Acad. Sci. U.S.A. 96:4868-4873(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "HDAC4 deacetylase associates with and represses the MEF2 transcription factor."EMBO J. 18:5099-5107(1999) [PubMed] [Europe PMC] [Abstract]
  6. "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."Mol. Cell. Biol. 19:7816-7827(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of histone deacetylase 4 by binding of 14-3-3 proteins."Mol. Cell. Biol. 20:6904-6912(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking."J. Biol. Chem. 276:35042-35048(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a signal-responsive nuclear export sequence in class II histone deacetylases."Mol. Cell. Biol. 21:6312-6321(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases."Mol. Endocrinol. 15:1318-1328(2001) [PubMed] [Europe PMC] [Abstract]
  11. "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."EMBO J. 21:2682-2691(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases."Int. J. Cancer 121:265-275(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells."J. Biol. Chem. 282:7219-7231(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems."Am. J. Hum. Genet. 87:219-228(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX."Nucleic Acids Res. 38:2813-2824(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."Cancer Res. 74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock."Sci. Signal. 5:RA39-RA39(2012) [PubMed] [Europe PMC] [Abstract]
  23. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  24. "20 ans apres: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition." Eur. J. Hum. Genet. 22:776-783(2014) [PubMed] [Europe PMC] [Abstract]