Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPE905Hu01 | Recombinant Histone Deacetylase 5 (HDAC5) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAE905Hu21 | Monoclonal Antibody to Histone Deacetylase 5 (HDAC5) | WB; IHC; ICC; IP. |
PAE905Hu01 | Polyclonal Antibody to Histone Deacetylase 5 (HDAC5) | WB; IHC; ICC; IP. | |
Assay Kits | SEE905Hu | ELISA Kit for Histone Deacetylase 5 (HDAC5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Histone Deacetylase 5 (HDAC5) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Histone Deacetylase 5 (HDAC5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Histone Deacetylase 5 (HDAC5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Histone Deacetylase 5 (HDAC5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Histone Deacetylase 5 (HDAC5) | ELISA Kit Customized Service Offer |
- "Three proteins define a class of human histone deacetylases related to yeast Hda1p."Proc. Natl. Acad. Sci. U.S.A. 96:4868-4873(1999) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Characterization of human colon cancer antigens recognized by autologous antibodies."Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
- "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)."Biochim. Biophys. Acta 1493:342-348(2000) [PubMed] [Europe PMC] [Abstract]
- "BCoR, a novel corepressor involved in BCL-6 repression."Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract]
- "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation."Nature 408:106-111(2000) [PubMed] [Europe PMC] [Abstract]
- "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5."Proc. Natl. Acad. Sci. U.S.A. 97:14400-14405(2000) [PubMed] [Europe PMC] [Abstract]
- "Identification of a signal-responsive nuclear export sequence in class II histone deacetylases."Mol. Cell. Biol. 21:6312-6321(2001) [PubMed] [Europe PMC] [Abstract]
- "Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes."Proc. Natl. Acad. Sci. U.S.A. 99:13425-13430(2002) [PubMed] [Europe PMC] [Abstract]
- "Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers."Biochem. Biophys. Res. Commun. 300:391-396(2003) [PubMed] [Europe PMC] [Abstract]
- "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases."Int. J. Cancer 121:265-275(2007) [PubMed] [Europe PMC] [Abstract]
- "Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion."J. Biol. Chem. 282:35687-35694(2007) [PubMed] [Europe PMC] [Abstract]
- "AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5."Diabetes 57:860-867(2008) [PubMed] [Europe PMC] [Abstract]
- "Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis."J. Biol. Chem. 283:14590-14599(2008) [PubMed] [Europe PMC] [Abstract]
- "Human BAHD1 promotes heterochromatic gene silencing."Proc. Natl. Acad. Sci. U.S.A. 106:13826-13831(2009) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases."FEBS Lett. 584:1103-1110(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."Cancer Res. 74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]