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Histone Deacetylase 7 (HDAC7)

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HDAC7A

Histone Deacetylase 7 (HDAC7)
CCC E907
HGNC 14067
MGI 1891835
PubMed 21324898
UniProt Q8WUI4
Wiki HDAC7A
This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via transcriptional corepressor SMRT. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene. Dot blot analysis of more than 40 human tissues showed that highest expression of HDAC7 was in adult and fetal thymus. In situ hybridization analysis revealed most abundant expression of HDAC7 in the cortical region of thymus. Flow cytometric analysis demonstrated highest HDAC7 expression during the double-positive stage of thymocyte maturation. either the amino or the carboxyl terminus of HDAC7 is sufficient for transcriptional repression and that the repression of HDAC7 is insensitive to trichostatin A, indicating that HDAC7 represses Mitf at least in part by deacetylation-independent mechanism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE907Hu01 Recombinant Histone Deacetylase 7 (HDAC7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 7 (HDAC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 7 (HDAC7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 7 (HDAC7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 7 (HDAC7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Deacetylase 7 (HDAC7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Deacetylase 7 (HDAC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Deacetylase 7 (HDAC7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Deacetylase 7 (HDAC7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Deacetylase 7 (HDAC7) ELISA Kit Customized Service Offer
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  10. "Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2."EMBO J. 26:4619-4633(2007) [PubMed] [Europe PMC] [Abstract]
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  12. "FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression."Proc. Natl. Acad. Sci. U.S.A. 104:4571-4576(2007) [PubMed] [Europe PMC] [Abstract]
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  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases."FEBS Lett. 584:1103-1110(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
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  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity."J. Biol. Chem. 283:11355-11363(2008) [PubMed] [Europe PMC] [Abstract]
  22. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]