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Methyl CpG Binding Domain Protein 3 (MBD3)

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Methyl-CpG-binding protein MBD3

Methyl CpG Binding Domain Protein 3 (MBD3)
CCC E922
HGNC 6918
MGI 1333812
PubMed 22196727
RGD 1307389
UniProt O95983
Wiki MBD3
Methyl-CpG-binding domain protein 3 is a protein encoded by the MBD3 gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methyl CpG Binding Domain Protein 3 (MBD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methyl CpG Binding Domain Protein 3 (MBD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methyl CpG Binding Domain Protein 3 (MBD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methyl CpG Binding Domain Protein 3 (MBD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methyl CpG Binding Domain Protein 3 (MBD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methyl CpG Binding Domain Protein 3 (MBD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methyl CpG Binding Domain Protein 3 (MBD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methyl CpG Binding Domain Protein 3 (MBD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methyl CpG Binding Domain Protein 3 (MBD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methyl CpG Binding Domain Protein 3 (MBD3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methyl CpG Binding Domain Protein 3 (MBD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methyl CpG Binding Domain Protein 3 (MBD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methyl CpG Binding Domain Protein 3 (MBD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methyl CpG Binding Domain Protein 3 (MBD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methyl CpG Binding Domain Protein 3 (MBD3) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a family of mammalian methyl-CpG binding proteins."Mol. Cell. Biol. 18:6538-6547(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase."Genes Cells 5:677-688(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1."J. Biol. Chem. 276:6817-6824(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2."J. Biol. Chem. 277:35434-35439(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3."J. Biol. Chem. 277:40958-40966(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and functional characterization of the p66/p68 components of the MeCP1 complex."Mol. Cell. Biol. 22:536-546(2002) [PubMed] [Europe PMC] [Abstract]
  10. "MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation."Cell 119:75-86(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks."Mol. Cell. Biol. 28:5912-5923(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences."Nucleic Acids Res. 41:3010-3021(2013) [PubMed] [Europe PMC] [Abstract]
  20. "MBD3 localizes at promoters, gene bodies and enhancers of active genes."PLoS Genet. 9:E1004028-E1004028(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA."J. Biol. Chem. 289:1294-1302(2014) [PubMed] [Europe PMC] [Abstract]