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Nuclear Transport Factor 2 Like Export Factor 1 (NXT1)

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P15; MTR2; NTF2 Like Export Factor 1; NTF2 Related Export Protein 1

Nuclear Transport Factor 2 Like Export Factor 1 (NXT1)
CCC E925
HGNC 15913
MGI 1929619
PubMed 10848583
RGD 1309327
UniProt Q9UKK6
Wiki NXT1
NTF2-related export protein 1 is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways.
It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Transport Factor 2 Like Export Factor 1 (NXT1) ELISA Kit Customized Service Offer
  1. "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export."Mol. Cell. Biol. 19:8616-8624(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro."Mol. Cell. Biol. 20:4562-4571(2000) [PubMed] [Europe PMC] [Abstract]
  5. "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells."Mol. Cell. Biol. 21:2545-2554(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA."EMBO J. 28:556-567(2009) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor."Mol. Cell 8:645-656(2001) [PubMed] [Europe PMC] [Abstract]