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Vav 3 Oncogene (VAV3)

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Vav 3 Guanine Nucleotide Exchange Factor

Vav 3 Oncogene (VAV3)
CCC E929
HGNC 12659
MGI 1888518
PubMed 22692505
RGD 1565941
UniProt Q9UKW4
Wiki VAV3
Guanine nucleotide exchange factor VAV3 is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations.
This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. VAV proteins are an essential and direct link between receptors with intrinsic or associated tyrosine kinase activity and the mitogenic and cytoskeletal pathways regulated by Rho/Rac proteins .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE929Hu01 Recombinant Vav 3 Oncogene (VAV3) Positive Control; Immunogen; SDS-PAGE; WB.
RPE929Hu02 Recombinant Vav 3 Oncogene (VAV3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE929Hu01 Polyclonal Antibody to Vav 3 Oncogene (VAV3) WB; IHC
PAE929Hu02 Polyclonal Antibody to Vav 3 Oncogene (VAV3) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Vav 3 Oncogene (VAV3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vav 3 Oncogene (VAV3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vav 3 Oncogene (VAV3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vav 3 Oncogene (VAV3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vav 3 Oncogene (VAV3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vav 3 Oncogene (VAV3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vav 3 Oncogene (VAV3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vav 3 Oncogene (VAV3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vav 3 Oncogene (VAV3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vav 3 Oncogene (VAV3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vav 3 Oncogene (VAV3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vav 3 Oncogene (VAV3) ELISA Kit Customized Service Offer
  1. "Non-stoichiometric reduced complexity probes for cDNA arrays."Nucleic Acids Res. 26:3883-3891(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins."Mol. Cell. Biol. 19:7870-7885(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation."Mol. Cell. Biol. 20:9212-9224(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity."Oncogene 21:7720-7729(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."Mol. Cell. Biol. 26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the CH domain from human VAV-3 protein."Submitted (DEC-2006) to the PDB data bank