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Ring Finger Protein 139 (RNF139)

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HRCA1; RCA1; TRC8; Translocation in renal carcinoma on chromosome 8 protein; E3 ubiquitin-protein ligase RNF139

Ring Finger Protein 139 (RNF139)
CCC E934
HGNC 17023
MGI 1923091
PubMed 19642973
RGD 1306670
UniProt Q8WU17
Wiki RNF139
RING finger protein 139 is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. The gene showed similarity to the hereditary basal cell carcinoma/segment polarity gene, 'Patched.' This similarity involves 2 regions of 'Patched,' the putative sterol-sensing domain and the second extracellular loop that participates in the binding of Sonic hedgehog (SHH). In the 3;8 translocation, TRC8 was fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the FHIT coding region was maintained and expressed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 139 (RNF139) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 139 (RNF139) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 139 (RNF139) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 139 (RNF139) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 139 (RNF139) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 139 (RNF139) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 139 (RNF139) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 139 (RNF139) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 139 (RNF139) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 139 (RNF139) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 139 (RNF139) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 139 (RNF139) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 139 (RNF139) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 139 (RNF139) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 139 (RNF139) ELISA Kit Customized Service Offer
  1. "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8."Proc. Natl. Acad. Sci. U.S.A. 95:9572-9577(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Pancreas.
  4. "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination."Proc. Natl. Acad. Sci. U.S.A. 96:11364-11369(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway."Oncogene 21:3507-3516(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene."Oncogene 26:2263-2271(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage."J. Biol. Chem. 284:28995-29004(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER."J. Cell Biol. 186:685-692(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways."Mol. Cancer Res. 8:93-106(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u."EMBO J. 33:2492-2506(2014) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]