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Ring Finger Protein 20 (RNF20)

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BRE1A; hBRE1; BRE1; E3 ubiquitin-protein ligase BRE1A

Ring Finger Protein 20 (RNF20)
CCC E949
HGNC 10062
MGI 1925927
PubMed 16337599
RGD 1311936
UniProt Q5VTR2
Wiki RNF20
E3 ubiquitin-protein ligase BRE1A shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3. In cells lacking the euchromatin-associated histone variant H2A.Z, Bre1, Rad6, and Lge1 were each essential for cell viability, supporting redundant functions for H2B ubiquitination and H2A substitution in the formation of active chromatin. Analysis of mutants demonstrated a function for Bre1/Lge1-dependent H2B monoubiquitination in the control of cell size. Reduction of BRE1A by RNA interference decreased endogenous H2B ubiquitylation, activator-dependent transcription, and H3 lys4 and lys79 methylation. BRE1A interacted with p53 (TP53) directly and was recruited to the MDM2 promoter in a p53-dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 20 (RNF20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 20 (RNF20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 20 (RNF20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 20 (RNF20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 20 (RNF20) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 20 (RNF20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 20 (RNF20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 20 (RNF20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 20 (RNF20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 20 (RNF20) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 20 (RNF20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 20 (RNF20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 20 (RNF20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 20 (RNF20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 20 (RNF20) ELISA Kit Customized Service Offer
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  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]