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Ring Finger Protein 19A (RNF19A)

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DORFIN; RNF19; Double ring-finger protein; E3 ubiquitin-protein ligase RNF19A

Ring Finger Protein 19A (RNF19A)
CCC E950
HGNC 13432
MGI 1353623
PubMed 11237715
RGD 1307807
UniProt Q9NV58
Wiki RNF19A
E3 ubiquitin-protein ligase RNF19A is an enzyme contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes.
This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 19A (RNF19A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 19A (RNF19A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 19A (RNF19A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 19A (RNF19A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 19A (RNF19A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 19A (RNF19A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 19A (RNF19A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 19A (RNF19A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 19A (RNF19A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 19A (RNF19A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 19A (RNF19A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 19A (RNF19A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 19A (RNF19A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 19A (RNF19A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 19A (RNF19A) ELISA Kit Customized Service Offer
  1. "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity."Biochem. Biophys. Res. Commun. 281:706-713(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity."J. Biol. Chem. 277:36793-36798(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1."J. Biol. Chem. 278:29106-29114(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders."J. Biol. Chem. 279:51376-51385(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin."J. Biol. Chem. 281:11610-11617(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]