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Ring Finger Protein 7 (RNF7)

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ROC2; SAG; CKBBP1; Zinc RING Finger Protein SAG; Regulator Of Cullins 2; CKII beta-binding protein 1; Regulator of cullins 2; Sensitive to apoptosis gene protein

Ring Finger Protein 7 (RNF7)
CCC E956
HGNC 10070
MGI 1337096
PubMed 23136067
RGD 1311048
UniProt Q9UBF6
Wiki RNF7
RING-box protein 2 is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction.
This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 7 (RNF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 7 (RNF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 7 (RNF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 7 (RNF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 7 (RNF7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 7 (RNF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 7 (RNF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 7 (RNF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 7 (RNF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 7 (RNF7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 7 (RNF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 7 (RNF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 7 (RNF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 7 (RNF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 7 (RNF7) ELISA Kit Customized Service Offer
  1. "Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif."Biochem. Biophys. Res. Commun. 263:743-748(1999) [PubMed] [Europe PMC] [Abstract]
  2. "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity."Mol. Cell 3:535-541(1999) [PubMed] [Europe PMC] [Abstract]
  3. "SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents."Mol. Cell. Biol. 19:3145-3155(1999) [PubMed] [Europe PMC] [Abstract]
  4. "SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes."DNA Cell Biol. 20:425-434(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation."Oncogene 19:2855-2866(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1."J. Biol. Chem. 278:28462-28469(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification."Mol. Cell 33:483-495(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the RING domain of the human RING-box protein 2."Submitted (AUG-2007) to the PDB data bank