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Poly/rC Binding Protein 1 (PCBP1)

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HNRPE1; HNRPX; hnRNP-E1; hnRNP-X; Heterogeneous Nuclear Ribonucleoprotein E1; Alpha-CP1; Nucleic acid-binding protein SUB2.3

Poly/rC Binding Protein 1 (PCBP1)
CCC E963
HGNC 8647
MGI 1345635
PubMed 18511687
UniProt Q15365
Wiki PCBP1
PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly/rC Binding Protein 1 (PCBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly/rC Binding Protein 1 (PCBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly/rC Binding Protein 1 (PCBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly/rC Binding Protein 1 (PCBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly/rC Binding Protein 1 (PCBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poly/rC Binding Protein 1 (PCBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poly/rC Binding Protein 1 (PCBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poly/rC Binding Protein 1 (PCBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poly/rC Binding Protein 1 (PCBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly/rC Binding Protein 1 (PCBP1) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE963Po01 Recombinant Poly/rC Binding Protein 1 (PCBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE963Po01 Polyclonal Antibody to Poly/rC Binding Protein 1 (PCBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Poly/rC Binding Protein 1 (PCBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poly/rC Binding Protein 1 (PCBP1) ELISA Kit Customized Service Offer
  1. "Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains."Eur. J. Biochem. 230:447-453(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of two KH domain proteins in the alpha-globin mRNP stability complex."EMBO J. 14:4357-4364(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K."Nucleic Acids Res. 22:959-964(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Structure and RNA binding of the third KH domain of poly(C)-binding protein 1."Nucleic Acids Res. 33:1213-1221(2005) [PubMed] [Europe PMC] [Abstract]