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Ring Finger Protein 34 (RNF34)

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CARP-1; RIF; RFI; RIFF; Caspases-8 and -10-associated RING finger protein 1; FYVE-RING finger protein Momo; Human RING finger homologous to inhibitor of apoptosis protein

Ring Finger Protein 34 (RNF34)
CCC E964
HGNC 17297
MGI 2153340
PubMed 22064484
RGD 628636
UniProt Q969K3
Wiki RNF34
E3 ubiquitin-protein ligase RNF34 is an enzyme contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein.
This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 34 (RNF34) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 34 (RNF34) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 34 (RNF34) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 34 (RNF34) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 34 (RNF34) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 34 (RNF34) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 34 (RNF34) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 34 (RNF34) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 34 (RNF34) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 34 (RNF34) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 34 (RNF34) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 34 (RNF34) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 34 (RNF34) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 34 (RNF34) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 34 (RNF34) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer."Oncogene 21:5024-5030(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth."Proc. Natl. Acad. Sci. U.S.A. 101:6170-6175(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Overexpression of hRFI (human RING finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells."Mol. Cancer Ther. 4:743-750(2005) [PubMed] [Europe PMC] [Abstract]
  6. "CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation."J. Biol. Chem. 282:3273-3281(2007) [PubMed] [Europe PMC] [Abstract]
  7. "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2."Cell Cycle 7:670-682(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Response: CARP1 regulates induction of NF-kappaB by TNFalpha."Curr. Biol. 19:R17-R19(2009)
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism."Mol. Cell. Biol. 32:266-275(2012) [PubMed] [Europe PMC] [Abstract]
  13. "The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway."Cell. Physiol. Biochem. 33:1954-1962(2014) [PubMed] [Europe PMC] [Abstract]