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Eukaryotic Translation Initiation Factor 2B1 (EIF2B1)

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EIF-2B; EIF-2Balpha; EIF2B; EIF2BA; eIF-2B GDP-GTP exchange factor subunit alpha

Eukaryotic Translation Initiation Factor 2B1 (EIF2B1)
CCC E980
HGNC 3257
MGI 2384802
PubMed 17353931
RGD 620819
UniProt Q14232
Wiki EIF2B1
EIF2B is a GTP exchange factor that is essential for protein synthesis. Its substrate is EIF2. EIF2B consists of alpha, beta (EIF2B2), gamma (EIF2B3), delta (EIF2B4), and epsilon (EIF2B5) subunits.
Flowers et al. (1995) cloned a rat cDNA encoding Eif2b1. The deduced 305-amino acid rat protein is 92% identical to the human protein. By Northern blot analysis, Flowers et al. (1995) detected equivalent expression of rat Eif2b1 in all tissues tested; in contrast, Eif2b5 is predominantly expressed in testis. Leukoencephalopathy with vanishing white matter (VWM) is an autosomal recessive disorder characterized by a chronic and progressive course with additional episodes of rapid deterioration provoked by fever and minor head trauma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B1 (EIF2B1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter."Ann. Neurol. 51:264-270(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of ten novel mutations in patients with eIF2B-related disorders."Hum. Mutat. 25:411-411(2005) [PubMed] [Europe PMC] [Abstract]