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Eukaryotic Translation Initiation Factor 2B4 (EIF2B4)

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EIF-2B; EIF2B; EIF2Bdelta; EIF2BD; eIF-2B GDP-GTP exchange factor subunit delta

Eukaryotic Translation Initiation Factor 2B4 (EIF2B4)
CCC E984
HGNC 3260
MGI 95300
PubMed 8929216
RGD 620208
UniProt Q9UI10
Wiki EIF2B4
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy.
Eif2b4, one containing 544 amino acids and the other containing 524 amino acids. The isoforms differ at their N termini. Northern blot analysis revealed wide expression of a 1.9-kb Eif2b4 transcript in mouse. Western blot analysis showed expression of an approximately 60-kD protein, close to the predicted size. The 525-amino acid rat protein is 96% identical to the 524-amino acid mouse isoform.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B4 (EIF2B4) ELISA Kit Customized Service Offer
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  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter."Ann. Neurol. 51:264-270(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Ovarian failure related to eukaryotic initiation factor 2B mutations."Am. J. Hum. Genet. 72:1544-1550(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of ten novel mutations in patients with eIF2B-related disorders."Hum. Mutat. 25:411-411(2005) [PubMed] [Europe PMC] [Abstract]