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Eukaryotic Translation Initiation Factor 2B2 (EIF2B2)

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EIF2B; EIF-2Bbeta; EIF2BB; eIF-2B GDP-GTP exchange factor subunit beta

Eukaryotic Translation Initiation Factor 2B2 (EIF2B2)
CCC E989
HGNC 3258
MGI 2145118
PubMed 22285377
RGD 620820
UniProt P49770
Wiki EIF2B2
Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1), beta (EIF2B2), gamma (EIF2B3), delta (EIF2B4), and epsilon (EIF2B5) subunits. EIF2B activates its EIF2 substrate by exchanging EIF2-bound GDP for GTP.Fogli et al. (2004) measured the guanine nucleotide exchange factor (GEF) activity of EIF2B in transformed lymphocytes from 30 patients with leukoencephalopathies with homozygous or compound heterozygous mutations in EIF2B2, EIF2B3, EIF2B4, and EIF2B5 compared to 10 unaffected heterozygotes and 22 controls with no EIF2B mutation. A significant decrease of 20 to 70% in GEF activity was observed in all mutated cells, and the extent of the decrease correlated with age at onset of disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE989Hu01 Recombinant Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE989Mu01 Recombinant Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2B2 (EIF2B2) ELISA Kit Customized Service Offer
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  11. "Vanishing white matter disease: an Italian case with A638G mutation in exon 5 of EIF2B2 gene, an unusual early onset and a long course."Neurol. Sci. 34:1235-1238(2013) [PubMed] [Europe PMC] [Abstract]