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Eukaryotic Translation Initiation Factor 2C1 (EIF2C1)

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AGO1; EIF2C; GERP95; Q99; Protein Argonaute-1; Argonaute RISC catalytic component 1; Putative RNA-binding protein Q99

Eukaryotic Translation Initiation Factor 2C1 (EIF2C1)
CCC E991
HGNC 3262
MGI 2446630
PubMed 15152257
RGD 1304619
UniProt Q9UL18
Wiki EIF2C1
EIF2C1 encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.To obtain genomic sequence information, they isolated a P1 genomic clone containing the EIF2C1 locus. The human EIF2C1 gene encodes a protein of 857 amino acids. The 2,571-bp open reading frame is flanked by 238 bp of 5-prime sequence and an extremely large 3-prime untranslated region with multiple short repeated segments composed of mono-, tri-, or quatronucleotides interspersed throughout.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE991Hu01 Recombinant Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE991Hu01 Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) WB; IHC; ICC; IP.
Assay Kits SEE991Hu ELISA Kit for Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2C1 (EIF2C1) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54."PLoS Biol. 4:E210-E210(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Importance of translation and nonnucleolytic ago proteins for on-target RNA interference."Curr. Biol. 18:1327-1332(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs."Cell 136:496-507(2009) [PubMed] [Europe PMC] [Abstract]
  11. "LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing."Proc. Natl. Acad. Sci. U.S.A. 107:12499-12504(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain."Nature 429:318-322(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Eukaryote-specific insertion elements control human ARGONAUTE slicer activity."Cell Rep. 3:1893-1900(2013) [PubMed] [Europe PMC] [Abstract]
  16. "The making of a slicer: activation of human Argonaute-1."Cell Rep. 3:1901-1909(2013) [PubMed] [Europe PMC] [Abstract]