≡

Eukaryotic Translation Initiation Factor 3M (EIF3M)

[Edit]

PCID1; HFLB5; GA17; eIF3m; hfl-B5; PCI Domain Containing 1; Herpesvirus Entry Mediator; Fetal lung protein B5; PCI domain-containing protein 1

Eukaryotic Translation Initiation Factor 3M (EIF3M)
CCC E997
HGNC 24460
MGI 1351744
PubMed 19483676
RGD 1565840
UniProt Q7L2H7
Wiki EIF3M
HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV) The predicted 374-amino acid type II membrane protein contains 2 N-glycosylation sites and a C-terminal heptad repeat that forms a coiled-coil structure. HFLB5 lacks a signal peptide. Microscopic, immunoprecipitation, Western blot, and FACS analyses demonstrated that the HFLB5 C terminus is exposed extracellularly on the cell surface. Northern blot and RT-PCR analyses of human tissues and cell lines revealed broad expression of a 1.3-kb HFLB5 transcript. Entry of HSV into HFLB5-expressing porcine and human cells could be blocked by a 30-mer peptide identical to the HFLB5 C-terminal coiled-coil region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE997Hu01 Recombinant Eukaryotic Translation Initiation Factor 3M (EIF3M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE997Hu01 Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3M (EIF3M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3M (EIF3M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3M (EIF3M) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3M (EIF3M) ELISA Kit Customized Service Offer
  1. "A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins."J. Virol. 79:7419-7430(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (MAR-2008) to UniProtKB
  6. "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells."Brain Res. 1170:129-139(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP."Genes Dev. 18:3078-3093(2004) [PubMed] [Europe PMC] [Abstract]
  8. "PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes."BMC Biol. 3:14-14(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The C-terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection."J. Virol. 79:7431-7437(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association."RNA 11:470-486(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."J. Biol. Chem. 281:22917-22932(2006) [PubMed] [Europe PMC] [Abstract]
  13. "CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo."Mol. Cell. Biol. 27:4526-4540(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry."Mol. Cell. Proteomics 6:1135-1146(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3."Proc. Natl. Acad. Sci. U.S.A. 105:18139-18144(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]