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Eukaryotic Translation Initiation Factor 3C (EIF3C)

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EIF3S8; eIF3-p110; eIF3c; Eukaryotic translation initiation factor 3 subunit 8

Eukaryotic Translation Initiation Factor 3C (EIF3C)
CCC E999
HGNC 3279
MGI 1926966
PubMed 23623922
RGD 1308871
UniProt Q99613
Wiki EIF3C
Eukaryotic initiation factor-3 (eIF3) is the largest of the eIFs and consists of at least 10 nonidentical subunits in mammals.The 115-kD component of HeLa cell eIF3 is actually composed of 2 proteins, p116 (PRT1) and p110. By screening a HeLa cell expression library with antibodies against the 115-kD band, these authors identified cDNAs encoding p110. The predicted 913-amino acid p110 protein has a pI of 5.8 and is unrelated to p116. p110 shares 31% identity to the S. cerevisiae Nip1 protein, which is thought to be involved in nuclear import and the initiation phase of protein synthesis.The p116, p110, and p36 subunits localize on 40S ribosomes in cells active in translation and coimmunoprecipitate with p170, indicating that these proteins are integral components of eIF3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3C (EIF3C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3C (EIF3C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3C (EIF3C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3C (EIF3C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3C (EIF3C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3C (EIF3C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3C (EIF3C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3C (EIF3C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3C (EIF3C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3C (EIF3C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3C (EIF3C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3C (EIF3C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3C (EIF3C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3C (EIF3C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3C (EIF3C) ELISA Kit Customized Service Offer
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  2. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3."Eur. J. Biochem. 270:4133-4139(2003) [PubMed] [Europe PMC] [Abstract]
  7. "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events."Cell 123:569-580(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association."RNA 11:470-486(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54."Virology 340:116-124(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."J. Biol. Chem. 281:22917-22932(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56."J. Biol. Chem. 281:34064-34071(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Reconstitution reveals the functional core of mammalian eIF3."EMBO J. 26:3373-3383(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Human INT6/eIF3e is required for nonsense-mediated mRNA decay."EMBO Rep. 8:596-602(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry."Mol. Cell. Proteomics 6:1135-1146(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3."Proc. Natl. Acad. Sci. U.S.A. 105:18139-18144(2008) [PubMed] [Europe PMC] [Abstract]
  16. "IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR."RNA 15:1528-1542(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Human ALKBH4 interacts with proteins associated with transcription."PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Structural roles for human translation factor eIF3 in initiation of protein synthesis."Science 310:1513-1515(2005) [PubMed] [Europe PMC] [Abstract]