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Eukaryotic Translation Initiation Factor 3E (EIF3E)

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EIF3S6; EIF3-P48; INT6; eIF3-p46; eIF3e; Eukaryotic translation initiation factor 3 subunit 6; Viral integration site protein INT-6 homolog

Eukaryotic Translation Initiation Factor 3E (EIF3E)
CCC F001
HGNC 3277
MGI 99257
PubMed 22907435
RGD 1311521
UniProt P60228
By searching an EST database with the partial protein sequence of the rabbit eIF3-p48 subunit, Asano et al. (1997) identified cDNAs encoding human p48. The predicted human p48 protein contains 445 amino acids. Recombinant p48 coimmunoprecipitated with eIF3 and with the eIF3-p170 subunit. Northern blot analysis revealed that p48 is expressed as a 1.6-kb mRNA in HeLa cells. Asano et al. found that human p48 is identical to the mouse int6 gene product. The mouse int6 gene is a site where mouse mammary tumor virus (MMTV) frequently integrates, which may result in the expression of a truncated int6 protein. These authors also noted that int6 has been identified as a human protein that binds to the human T-cell leukemia virus type I Tax protein, leading to the translocation of int6 from the nucleus to the cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3E (EIF3E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3E (EIF3E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3E (EIF3E) Polyclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3E (EIF3E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3E (EIF3E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3E (EIF3E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3E (EIF3E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3E (EIF3E) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 3E (EIF3E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 3E (EIF3E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 3E (EIF3E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 3E (EIF3E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 3E (EIF3E) ELISA Kit Customized Service Offer
  1. "The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome."J. Biol. Chem. 272:23477-23480(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas."Genomics 46:155-158(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein."Science 273:951-953(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Divergent subcellular locations of HTLV-I Tax and Int-6: a contrast between in vitro protein-protein binding and intracellular protein colocalization."J. Biomed. Sci. 4:229-234(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAR-2008) to UniProtKB
  7. "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies."J. Cell Sci. 112:3331-3342(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits."J. Biol. Chem. 276:34948-34957(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3."J. Biol. Chem. 276:45988-45995(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome."FEBS Lett. 527:15-21(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association."RNA 11:470-486(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54."Virology 340:116-124(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."J. Biol. Chem. 281:22917-22932(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56."J. Biol. Chem. 281:34064-34071(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Reconstitution reveals the functional core of mammalian eIF3."EMBO J. 26:3373-3383(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Human INT6/eIF3e is required for nonsense-mediated mRNA decay."EMBO Rep. 8:596-602(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation."J. Biol. Chem. 282:12707-12716(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain."J. Biol. Chem. 282:32414-32423(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry."Mol. Cell. Proteomics 6:1135-1146(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle."Oncogene 26:5132-5144(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3."Proc. Natl. Acad. Sci. U.S.A. 105:18139-18144(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  28. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Structural roles for human translation factor eIF3 in initiation of protein synthesis."Science 310:1513-1515(2005) [PubMed] [Europe PMC] [Abstract]