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Eukaryotic Translation Initiation Factor 4A2 (EIF4A2)

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EIF4A; BM-010; DDX2B; EIF4F; ATP-dependent RNA helicase eIF4A-2

Eukaryotic Translation Initiation Factor 4A2 (EIF4A2)
CCC F010
HGNC 3284
MGI 106906
PubMed 23559250
RGD 1309225
UniProt Q14240
Wiki EIF4A2
Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2 . The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation. The human homolog was expressed in all normal tissues examined, but in variable amounts, being highly expressed in skeletal muscle and ovary, and less abundantly in liver, kidney, and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF010Hu01 Recombinant Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF010Hu21 Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) WB; IHC; ICC; IP.
PAF010Hu01 Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) WB; IHC; ICC; IP.
Assay Kits SEF010Hu ELISA Kit for Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) ELISA Kit Customized Service Offer
  1. "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2."Cytogenet. Cell Genet. 71:385-388(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo."J. Biol. Chem. 276:29111-29115(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia."Gene 347:137-145(2005) [PubMed] [Europe PMC] [Abstract]
  6. "mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A."J. Virol. 79:9651-9664(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative structural analysis of human DEAD-box RNA helicases."PLoS ONE 5:E12791-E12791(2010) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]