Eukaryotic Translation Elongation Factor 1 Delta (EEF1d)

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EF-1D; guanine nucleotide exchange protein; Antigen NY-CO-4

Eukaryotic Translation Elongation Factor 1 Delta (EEF1d)
EEF1d encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined. The deduced 281-amino acid protein has a calculated molecular mass of 31 kD. It has an N-terminal leucine zipper domain and a C-terminal domain that is similar to that of EF1-beta and is predicted to show GDP/GTP exchange activity. EF1-delta also has a conserved serine phosphorylation site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF024Hu01 Recombinant Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF024Hu01 Polyclonal Antibody to Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF024Mu01 Recombinant Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF024Mu01 Polyclonal Antibody to Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) WB; IHC; ICC; IP.
Assay Kits SEF024Mu ELISA Kit for Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Elongation Factor 1 Delta (EEF1d) ELISA Kit Customized Service Offer
  1. "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta."Biochim. Biophys. Acta 1174:87-90(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of human colon cancer antigens recognized by autologous antibodies."Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (JUL-2004) to UniProtKB
  7. "Elongation factor 1 delta is enhanced following exposure to ionizing radiation."Cancer Res. 54:2541-2543(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta."J. Biol. Chem. 273:19840-19846(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteomic analysis of the human pituitary."Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing."EMBO Rep. 12:673-681(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of as a substrate for CK2."J. Proteome Res. 10:4887-4901(2011) [PubMed] [Europe PMC] [Abstract]
  27. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]