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Transcriptional Intermediary Factor 1 Gamma (TIF1g)

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TRIM33; PTC7; RFG7; TF1G; TIF1GAMMA; TIFGAMMA; Tripartite Motif-Containing 33; Ret-Fused Gene 7; RET-fused gene 7 protein; Ectodermin homolog

Transcriptional Intermediary Factor 1 Gamma (TIF1g)
CCC F056
HGNC 16290
MGI 2137357
PubMed 23154409
RGD 1307339
UniProt Q9UPN9
TIF1gis thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified. Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.
The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains:RING; B-box type 1 zinc finger; B-box type 2 zinc finger; and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcriptional Intermediary Factor 1 Gamma (TIF1g) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcriptional Intermediary Factor 1 Gamma (TIF1g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcriptional Intermediary Factor 1 Gamma (TIF1g) Polyclonal Antibody Customized Service Offer
Assay Kits SEF056Hu ELISA Kit for Transcriptional Intermediary Factor 1 Gamma (TIF1g) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcriptional Intermediary Factor 1 Gamma (TIF1g) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcriptional Intermediary Factor 1 Gamma (TIF1g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcriptional Intermediary Factor 1 Gamma (TIF1g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcriptional Intermediary Factor 1 Gamma (TIF1g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcriptional Intermediary Factor 1 Gamma (TIF1g) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcriptional Intermediary Factor 1 Gamma (TIF1g) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcriptional Intermediary Factor 1 Gamma (TIF1g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcriptional Intermediary Factor 1 Gamma (TIF1g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcriptional Intermediary Factor 1 Gamma (TIF1g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcriptional Intermediary Factor 1 Gamma (TIF1g) ELISA Kit Customized Service Offer
  1. "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family."Oncogene 18:1209-1217(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The tripartite motif family identifies cell compartments."EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas."Oncogene 18:4388-4393(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression."J. Mol. Biol. 320:629-644(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase."Cell 121:87-99(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway."Cell 125:929-941(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination."Cell 136:123-135(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]