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Replication Factor C5 (RFC5)

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RFC36; Activator 1 36 kDa subunit; Activator 1 subunit 5; Replication factor C 36 kDa subunit

Replication Factor C5 (RFC5)
CCC F077
HGNC 9973
MGI 1919401
PubMed 7774928
RGD 1309280
UniProt P40937
Wiki RFC5
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD.
RFC5 encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF077Hu01 Recombinant Replication Factor C5 (RFC5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Replication Factor C5 (RFC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C5 (RFC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C5 (RFC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C5 (RFC5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF077Mu01 Recombinant Replication Factor C5 (RFC5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Replication Factor C5 (RFC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C5 (RFC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C5 (RFC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C5 (RFC5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Factor C5 (RFC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Factor C5 (RFC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Factor C5 (RFC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Factor C5 (RFC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Factor C5 (RFC5) ELISA Kit Customized Service Offer
  1. "Homology in accessory proteins of replicative polymerases -- E. coli to humans."Nucleic Acids Res. 21:1-3(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]