≡

Mediator Complex Subunit 12 (MED12)

[Edit]

OPA1; CAGH45; HOPA; TNRC11; TRAP230; Trinucleotide Repeat Containing 11; Activator-recruited cofactor 240 kDa; Thyroid hormone receptor-associated 230 kDa; OPA-containing

Mediator Complex Subunit 12 (MED12)
CCC F092
HGNC 11957
MGI 1926212
PubMed 23178117
RGD 1585896
UniProt Q93074
Wiki MED12
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C.
The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 12 (MED12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 12 (MED12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 12 (MED12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 12 (MED12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 12 (MED12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 12 (MED12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 12 (MED12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 12 (MED12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 12 (MED12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 12 (MED12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 12 (MED12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 12 (MED12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 12 (MED12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 12 (MED12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 12 (MED12) ELISA Kit Customized Service Offer
  1. "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."Mol. Cell 3:361-370(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Association of an X-chromosome dodecamer insertional variant allele with mental retardation."Mol. Psychiatry 3:303-309(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA)."Hum. Genet. 105:174-178(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
  7. "cDNAs with long CAG trinucleotide repeats from human brain."Hum. Genet. 100:114-122(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
  9. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  10. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Mediator is a transducer of Wnt/beta-catenin signaling."J. Biol. Chem. 281:14066-14075(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Mediator modulates Gli3-dependent Sonic hedgehog signaling."Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene."J. Med. Genet. 44:472-477(2007) [PubMed] [Europe PMC] [Abstract]
  22. "A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome."Nat. Genet. 39:451-453(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Mutations in MED12 cause X-linked Ohdo syndrome."Am. J. Hum. Genet. 92:401-406(2013) [PubMed] [Europe PMC] [Abstract]