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Mediator Complex Subunit 7 (MED7)

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CRSP9; CRSP33; MED7; Cofactor Required For Sp1 Transcriptional Activation 9, 33kDa; Activator-recruited cofactor 34 kDa; Cofactor required for Sp1 transcriptional activation 9

Mediator Complex Subunit 7 (MED7)
CCC F097
HGNC 2378
MGI 2159682
PubMed 16189514
UniProt O43513
Wiki MED7
Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus.
MED7 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. CRSP behaves as a single complex of approximately 700 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 7 (MED7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 7 (MED7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 7 (MED7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 7 (MED7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 7 (MED7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 7 (MED7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 7 (MED7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 7 (MED7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 7 (MED7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 7 (MED7) ELISA Kit Customized Service Offer
  1. "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways."Proc. Natl. Acad. Sci. U.S.A. 95:8538-8543(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."Nature 397:446-450(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
  5. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  6. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."Nucleic Acids Res. 35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]