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Serine/Arginine Rich Splicing Factor 5 (SRSF5)

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SFRS5; HRS; SRP40; Delayed-early protein HRS; Pre-mRNA-splicing factor SRP40; Splicing factor, arginine/serine-rich 5

Serine/Arginine Rich Splicing Factor 5 (SRSF5)
CCC F105
HGNC 10787
MGI 98287
PubMed 23536862
RGD 3664
UniProt Q13243
SFRS5is 259 amino acids long and is highly basic. The sequence of HRS is related to the human SF2/ASF protein and the Drosophila B52/SRp55 protein. The latter has been shown to function in vitro to regulate 5-prime splice site selection. Northern blots showed highest levels of HRS transcription in the spleen and thymus, tissues with actively proliferating cells. The authors noted that HRS is likely to be a member of a larger family of regulators of alternative pre-mRNA splicing.
Human SRp40 is 99% similar at the amino acid level and 94% similar at the nucleotide level within the coding sequence to rat HRS. Recombinant SRp40 protein is active in constitutive splicing, as shown by its ability to complement a HeLa cell S100 extract deficient in SR proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 5 (SRSF5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 5 (SRSF5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 5 (SRSF5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 5 (SRSF5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 5 (SRSF5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 5 (SRSF5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 5 (SRSF5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 5 (SRSF5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 5 (SRSF5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 5 (SRSF5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Arginine Rich Splicing Factor 5 (SRSF5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 5 (SRSF5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 5 (SRSF5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Arginine Rich Splicing Factor 5 (SRSF5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Arginine Rich Splicing Factor 5 (SRSF5) ELISA Kit Customized Service Offer
  1. "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors."EMBO J. 14:4336-4349(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes."Gene 204:243-249(1997) [PubMed] [Europe PMC] [Abstract]
  7. "SR proteins: a conserved family of pre-mRNA splicing factors."Genes Dev. 6:837-847(1992) [PubMed] [Europe PMC] [Abstract]
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  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]